Joint supplement for a Great Dane showing rear weakness at 6

Rear-end weakness in a Great Dane at 6 is worth taking seriously — the breed ages fast and giant breeds carry a body weight that puts enormous cumulative load on hindquarter joints. Is the weakness symmetrical on both sides, or is he favouring one rear leg over the other?

That pattern — hesitation before stairs plus slipping on smooth floors — is the classic combination of reduced proprioception and hindquarter muscle weakness driven by joint pain. For a giant breed at this stage I'd go straight to 4Cyte Canine. Two pumps daily for the first four weeks at his size, then one to maintain. The Epiitalis compound is what makes it the right call here — it promotes cartilage cell regeneration rather than just managing inflammation, which matters when the joints are under the kind of load a Dane carries. You'll also want a non-slip mat at the foot of the stairs and in the kitchen while you wait for the supplement to take effect — the slipping itself becomes a secondary injury risk.